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A publication by Han et al about this topic provides a good introduction into the topic and has a list of potential alternate US Food and Drug Administration (FDA) cleared and uncleared glucose analyzers. Furthermore, this perception has resulted in a standstill in further development of the YSI 2300 for about four decades, and this device has not been substantially improved since the 1970s.īecause glucose measurement represents a core parameter of many activities in the diabetes world, YSI’s recent announcement to discontinue the YSI 2300 has stirred multiple activities. This perception has been a barrier discouraging reliance on other candidate comparator devices. The YSI 2300 became used so widely that many glucose meters and CGM manufacturers considered it to be a widely practiced procedure like an actual standard for comparison testing of glucose monitoring devices.
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Meanwhile, even as new glucose analyzers came on line (including small portable ones), glucose meter manufacturers (and later continuous glucose monitoring manufacturers) invested internally in YSI instruments, tied their development programs to that device, and thus resisted changing to other methods for comparison studies.

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For several decades, the YSI 2300 Stat Plus Glucose Lactate Analyzer (YSI 2300), manufactured by the US Company YSI, has been widely used as a comparator method in clinical and analytical studies of glucose.
